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## Сравнение молекул РНК: энергия связывания и статистические свойства случайных последовательностей

The paper discusses a new approach to developing tools for quantitatively analyzing the financial behavior of small and medium price-taking traders each possessing abilities to predict share price values for a set of financial securities traded in a stock exchange. Tools for forming and managing a trader’s portfolio of securities from this set are proposed. Particularly, it is shown that when the trader can treat share price values from the portfolio as random variables with known (to her) distributions, an optimal portfolio composition is found by solving a linear programming problem. Otherwise, this optimal composition is found as the trader’s equilibrium strategy in an antagonistic two-person game with the stock exchange being the other player. In this game on polyhedra of disjoint player strategies, described by systems of linear equations and inequalities of a balance kind, calculating saddle points is reduced to solving linear programming problems forming a dual pair.

Contents of the book is divided into 2 parts of deterministic and stochastic models of Operations Research.

The first part of "Deterministic models of Operations Research" - is the base section, in which the emphasis is on linear programming.

The second part - "Stochastic models of Operations Research" includes a model of reliability and queuing models. This is original material.

The textbook can be useful to students of undergraduate and graduate programs in areas of training in "Applied Mathematics", "Applied Mathematics and Computer Science", "Information systems and technologies", as well as graduate students and science teachers who are interested in the problems of optimization in stochastic models

We study the planar matching problem, defined by a symmetric random matrix with independent identically distributed entries, taking values 0 and 1. We show that the existence of a perfect planar matching structure is possible only above a certain critical density of allowed contacts, $p_{c}$. This problem has an important application for the prediction of the optimal folding of RNA-type polymers. Using an alternative formulation of the problem in terms of Dyck paths and a matrix model of planar contact structures, we provide an analytical estimation for the value of the transition point, $p_{c}$, in the thermodynamic limit. This estimation is close to the critical value, $p_{c}\approx 0.38$, obtained in numerical simulations based on an exact dynamic-programming algorithm. We characterize the corresponding critical behavior of the model and discuss the relation of the perfect-imperfect matching transition to the known molten-glass transition in the context of random RNA secondary structure's formation. In particular, we provide strong evidence supporting the conjecture that the molten-glass transition at $T=0$ occurs at $p_{c}$

The manual is devoted to the mathematical theory and methods of optimization applied to administrative decisions in economy. Volume 1 described approaches to mathematical modeling of management problems in economy and methods of mathematical programming tasks solution. Besides strict mathematical proofs, there are directing reasons, which is sometimes enough for understanding. There are many economic examples and exercises with detailed solutions. Readers are supposed to know the bases of the mathematical analysis and linear algebra, though necessary data from these courses in a concise form are provided in appendices.

A new statistical approach to alignment (finding the longest common subsequence) of two random RNA-type sequences is proposed. We have constructed a generalized ‘dynamic programming’ algorithm for finding the extreme value of the free energy of two noncoding RNAs. In our procedure, we take into account the binding free energy of two random heteropolymer chains which are capable of forming the cloverleaf-like spatial structures typical for RNA molecules. The algorithm is based on two observations: (i) the standard alignment problem can be considered as a zero-temperature limit of a more general statistical problem of binding of two associating heteropolymer chains; (ii) this last problem can be generalized naturally to consider sequences with hierarchical cloverleaf-like structures (i.e. of RNA type). The approach also permits us to perform a ‘secondary structure recovery’. Namely, we can predict the optimal secondary structures of interacting RNAs in a zero-temperature limit knowing only their primary sequences.

A method based on the spectral analysis of thermowave oscillations formed under the effect of radiation of lasers operated in a periodic pulsed mode is developed for investigating the state of the interface of multilayered systems. The method is based on high sensitivity of the shape of the oscillating component of the pyrometric signal to adhesion characteristics of the phase interface. The shape of the signal is quantitatively estimated using the correlation coefficient (for a film–interface system) and the transfer function (for multilayered specimens).

Let k be a field of characteristic zero, let G be a connected reductive algebraic group over k and let g be its Lie algebra. Let k(G), respectively, k(g), be the field of k- rational functions on G, respectively, g. The conjugation action of G on itself induces the adjoint action of G on g. We investigate the question whether or not the field extensions k(G)/k(G)^G and k(g)/k(g)^G are purely transcendental. We show that the answer is the same for k(G)/k(G)^G and k(g)/k(g)^G, and reduce the problem to the case where G is simple. For simple groups we show that the answer is positive if G is split of type A_n or C_n, and negative for groups of other types, except possibly G_2. A key ingredient in the proof of the negative result is a recent formula for the unramified Brauer group of a homogeneous space with connected stabilizers. As a byproduct of our investigation we give an affirmative answer to a question of Grothendieck about the existence of a rational section of the categorical quotient morphism for the conjugating action of G on itself.

Let G be a connected semisimple algebraic group over an algebraically closed field k. In 1965 Steinberg proved that if G is simply connected, then in G there exists a closed irreducible cross-section of the set of closures of regular conjugacy classes. We prove that in arbitrary G such a cross-section exists if and only if the universal covering isogeny Ĝ → G is bijective; this answers Grothendieck's question cited in the epigraph. In particular, for char k = 0, the converse to Steinberg's theorem holds. The existence of a cross-section in G implies, at least for char k = 0, that the algebra k[G]G of class functions on G is generated by rk G elements. We describe, for arbitrary G, a minimal generating set of k[G]G and that of the representation ring of G and answer two Grothendieck's questions on constructing generating sets of k[G]G. We prove the existence of a rational (i.e., local) section of the quotient morphism for arbitrary G and the existence of a rational cross-section in G (for char k = 0, this has been proved earlier); this answers the other question cited in the epigraph. We also prove that the existence of a rational section is equivalent to the existence of a rational W-equivariant map T- - - >G/T where T is a maximal torus of G and W the Weyl group.